Evaluation of oral fluralaner (Bravecto®) for efficacy against nymphs of Amblyomma americanum and Rhipicephalus sanguineus (sensu lato)

Table 1 Percent efficacy of fluralaner based on all live and live-fed Amblyomma americanum nymphs from control and treated dogs (Experiment 1). Each group had 10 dogs unless otherwise noted

Infestation day	Count day	Control		Fluralaner						Efficacy
Infestation day	Count day	GM (L)	GM (LF)	GM (L)	GM (LF)	t-value (L)	t-value (LF)	P-value (L)	P-value (LF)	% (L)	% (LF)
− 1	1	43.9	42.6	1.2	0.0	t_(18.0) = 10.5	t_(18.0) = 165.4	< 0.001	< 0.001	97.3	100
− 1	2	41.8	41.8	0.2	0.2	t_(18.0) = 27.9	t_(18.0) = 27.9	< 0.001	< 0.001	99.5	99.5
6	8	47.0	45.3	0.8	0.3	t_(9.0) = 16.8	t_(18.0) = 21.3	< 0.001	< 0.001	98.4	99.4
6	9	46.9	46.9	0.8	0.5	t_(18.0) = 18.3	t_(18.0) = 18.8	< 0.001	< 0.001	98.2	98.9
28	30	47.5	45.6	0.7	0.6	t_(9.0) = 10.8	t_(9.0) = 11.2	< 0.001	< 0.001	98.5	98.6
28	31	43.9	43.9	0.7	0.7	t_(18.0) = 12.9	t_(18.0) = 12.9	< 0.001	< 0.001	98.4	98.4
56	58	46.0 ^a	46.0^a	1.6	1.6	t_(8.8) = 8.7	t_(8.8) = 8.7	< 0.001	< 0.001	96.5	96.5
56	59	46.2 ^a	46.2^a	0.3	0.3	t_(8.9) = 18.9	t_(8.9) = 18.9	< 0.001	< 0.001	99.3	99.3
84	86	43.1^a	42.4^a	2.3	2.0	t_(9.2) = 5.5	t_(9.2) = 5.9	< 0.001	< 0.001	94.7	95.2
84	87	43.9 ^a	43.9^a	1.1	1.1	t_(17.0) = 6.7	t_(17.0) = 6.7	< 0.001	< 0.001	97.6	97.6

^aOnly nine dogs available for infestation due to one dog having inflammatory tick attachment site reactions
Abbreviations: GM, geometric mean; L, all live (attached and engorged, attached and not engorged, free and engorged, and free and not engorged); LF, live-fed (attached and engorged, attached and not engorged, and free and engorged)

ISSN: 1756-3305