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Fig. 7 | Parasites & Vectors

Fig. 7

From: Excretory/secretory products of Angiostrongylus cantonensis fifth-stage larvae induce endoplasmic reticulum stress via the Sonic hedgehog pathway in mouse astrocytes

Fig. 7

Excretory/secretory products induce GRP78 expression through the Shh signalling pathway. Cells were pre-treated with recombinant Shh (r-Shh), Shh agonist (SAG) and cyclopamine (Cyclo) for 1 h, then incubated with 250 μg/ml excretory/secretory products (ESPs) of A. cantonensis L5 for 12 h. The mRNA (a) and protein (b) expression levels were detected by real-time qPCR and western blotting. The data are expressed as the means ± SD from three independent experiments (n = 3). #P < 0.01 compared with the control; **P < 0.01 compared with cells exposed to ESPs

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Parasites & Vectors

ISSN: 1756-3305

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