Table 4 CO92 c-di-GMP diguanylate cyclases have similar contributing roles to blockage formation as their homologs in KIM6+
| Â | Y. pestis strain | |||||
|---|---|---|---|---|---|---|
CO92 | CO92 ΔhmsD::frt | CO92 ΔhmsT::frt | KIM6+a | KIM6+ ΔhmsDa | KIM6+ ΔhmsTa | |
Mean % reduction in mutant blockage vs parental strain | na | 82 | 39 | na | 92 | 57 |
Mean CFU/flea (0 dpi) | 3.1 × 104 | 9.4 × 103 | 2.3 × 104 | 1.3 × 105 | 5.1 × 104 | 5.2 × 104 |
Mean CFU/flea (28 dpi) | 1.3 × 106 | 7.9 × 105 | 3.7 × 105 | 5.4 × 105 | 3.0 × 105 | 4.7 × 105 |