Group | Abbreviation | Vaccine | Immunisation protocol | Challenge (E. maxima W) | n PRd (cages) | n LSe (pens) | n BWGf (pens) | ||
---|---|---|---|---|---|---|---|---|---|
Day 2 | Day 8 | Day 14 | Day 29 | Culled at day 35 | Culled at day 35 | Culled at day 41 | |||
1 | H2O-H2O | H2O | H2O | H2O | H2O | H2O | – | 7 | 11 |
H2O | 6 | – | – | ||||||
2 | H2O-Emax | H2O (no protection) | H2O | H2O | H2O | 10,000 | – | 7 | 11 |
300 | 6 | – | – | ||||||
3 | Emax-Emax | E. maxima W (‘full’ protection) | 100 | 500 | 3000 | 10,000 | – | 7 | 11 |
300 | 6 | – | – | ||||||
4 | Et[GPI]-Emax | Et[GPI]a,b (empty vector) | 100 | 500 | 3000 | 10,000 | – | 7 | 11 |
300 | 6 | – | – | ||||||
5 | Et[A]-Emax | Et[EmAMA1]a | 100 | 500 | 3000 | 10,000 | – | 7 | 11 |
300 | 6 | – | – | ||||||
6 | Et[A + I]-Emax | Et[EmAMA1] + Et[EmIMP1]a,c | 100 | 500 | 3000 | 10,000 | – | 7 | 11 |
300 | 6 | – | – |