Transcriptional responses in Parascaris univalens after in vitro exposure to ivermectin, pyrantel citrate and thiabendazole

Table 1 Samples included in the in vitro exposure experiment

Drug and concentration	Viability	Differentially expressed genes	Unknown genes (%)
IVM 10⁻⁹ M	3.5	256	44
IVM 10⁻¹¹ M	4.5	119	44
IVM 10⁻¹³ M	6.0	177	46
PYR 10⁻⁶ M	3.0	38	50
PYR 10⁻⁸ M	4.5	191	45
PYR 10⁻¹⁰ M	6.0	84	50
TBZ 10⁻⁵ M	4.0	154	46
TBZ 10⁻⁷ M	5.0	46	43
TBZ 10⁻⁹ M	5.0	161	51
Control 24 h^{+ DMSO}	6.0	–	–

Notes: Mean viability score of adult Parascaris univalens, number of differentially expressed genes (adjusted P < 0.05 and log2 fold change of ≥ 1 or ≤ − 1) and proportion of unknown differentially expressed genes after exposure to the anthelmintic drugs ivermectin (IVM), pyrantel citrate (PYR) and thiabendazole TBZ), at different concentrations for 24 h. The gene expression of drug-exposed worms was normalized to control 24 h^+DMSO

ISSN: 1756-3305