Table 2 The 10 most up- and downregulated genes (adjusted P-value < 0.05) in Parascaris univalens worms exposed to three different concentrations of the anthelmintic drugs ivermectin (IVM), pyrantel citrate (PYR) and thiabendazole (TBZ) for 24 h
Gene ID | Log2FC | Orthologue | Condition |
|---|---|---|---|
PgR001X_g190 | 23.45 | Uncharacterised | IVM 10−9 M |
PgR013_g129 | 8.93 | RPE Ribulose-phosphate 3-epimerase | IVM 10−13 M |
PgR047_g061 | 8.23 | GABRA6 Gamma-aminobutyric acid receptor subunit alpha-6 | IVM 10−9 M |
PgB04_g079 | 6.77 | RPL3 60S ribosomal protein L3 | IVM 10−13 M |
PgR010_g071 | 5.77 | Uncharacterised | IVM 10−9 M |
PgR152_g010 | 5.36 | COL9A1 Collagen alpha-1(IX) chain | IVM 10−11 M |
PgR045_g001 | 5.32 | Uncharacterised | IVM 10−9 M |
PgR004_g064 | 4.85 | Uncharacterised | IVM 10−13 M |
PgR001X_g079 | 4.35 | Uncharacterised | IVM 10−9 M |
PgB05_g040 | 4.30 | Uncharacterised | IVM 10−13 M |
PgB04_g079 | 9.10/5.51 | RPL3 60S ribosomal protein L3 | PYR 10−6 M/PYR 10−10 M |
PgE230_g001 | 8.25 | Uncharacterised | PYR 10−6 M |
PgR020_g019 | 6.13 | Uncharacterised | PYR 10−10 M |
PgR004_g204 | 5.88 | Uncharacterised | PYR 10−8 M |
PgR152_g010 | 5.67 | COL9A1 Collagen alpha-1(IX) chain | PYR 10−6 M |
PgR001X_g079 | 5.01 | Uncharacterised | PYR 10−8 M |
PgR099_g042 | 4.80 | hpo-4 Putative GPI-anchor transamidase | PYR 10−8 M |
PgE192_g001 | 3.71 | Uncharacterised | PYR 10−8 M |
PgR002_g035 | 3.63 | ani-2 Anillin-like protein 2 | PYR 10−6 M |
PgR123_g005 | 3.48 | Pym Partner of Y14 and mago | PYR 10−8 M |
PgR307_g002 | 12.41/11.44 | EDF1 Endothelial differentiation-related factor 1 homolog | TBZ 10−9 M/TBZ 10−5 M |
PgR256X_g003 | 8.82 | Uncharacterised | TBZ 10−9 M |
PgR010_g071 | 8.22 | Uncharacterised | TBZ 10−9 M |
PgR190X_g006 | 8.03 | Uncharacterised | TBZ 10−9 M |
PgR001X_g019 | 7.85 | Uncharacterised | TBZ 10−7 M |
PgR152_g010 | 7.15 | COL9A1 Collagen alpha-1(IX) chain | TBZ 10−5 M |
PgB04_g079 | 6.49 | RPL3 60S ribosomal protein L3 | TBZ 10−9 M |
PgR034_g082 | 6.33 | Uncharacterised | TBZ 10−9 M |
PgR099_g042 | 5.01 | hpo-4 Putative GPI-anchor transamidase | TBZ 10−7 M |
PgR001X_g079 | 4.76 | Uncharacterised | TBZ 10−9 M |
PgR166_g010 | − 7.80/− 5.92 | agmo-1 alkylglycerol monooxygenase | IVM 10−13 M/IVM 10−9 M |
PgR049_g007 | − 7.50 | Uncharacterised | IVM 10−13 M |
PgE193_g002 | − 6.88 | cyb-3 G2/mitotic-specific cyclin-B3 | IVM 10−9 M |
PgR260_g001 | − 6.74 | Eif4a3 Eukaryotic initiation factor 4A-III | IVM 10−9 M |
PgR005X_g207 | − 6.28 | cup-4 Acetylcholine receptor-like protein cup-4 | IVM 10−13 M |
PgE182_g003 | − 6.11 | ZFP36 mRNA decay activator protein | IVM 10−9 M |
PgR002_g265 | − 6.02 | Uncharacterised | IVM 10−9 M |
PgR022X_g031 | − 5.72 | Uncharacterised | IVM 10−13 M |
PgB32_g014 | − 5.71 | Uncharacterised | IVM 10−9 M |
PgE068_g001 | − 5.70 | Uncharacterised | IVM 10−9 M |
PgR022X_g031 | − 8.43 | Uncharacterised | PYR 10−6 M |
PgB08_g035 | − 8.13 | ZC116.3 Probable cubilin | PYR 10−8 M |
PgR389_g001 | − 7.93 | Uncharacterised | PYR 10−8 M |
PgR005X_g207 | − 7.90 | cup-4 Acetylcholine receptor-like protein cup-4 | PYR 10−6 M |
PgR049_g007 | − 7.84 | Uncharacterised | PYR 10−10 M |
PgB22_g038 | − 6.34 | F01G4.6 Phosphate carrier protein, mitochondrial | PYR 10−10 M |
PgR022X_g030 | − 5.72 | Uncharacterised | PYR 10−6 M |
PgB08_g034 | − 5.65 | ZC116.3 Probable cubilin | PYR 10−6 M |
PgR166_g010 | − 5.57 | agmo-1 Alkylglycerol monooxygenase | PYR 10−8 M |
PgR057_g068 | − 5.51 | Uncharacterised | PYR 10−10 M |
PgR012_g016 | − 13.72 | Uncharacterised | TBZ 10−9 M |
PgR049_g007 | − 9.59/− 8.19 | Uncharacterised | TBZ 10−7 M/TBZ 10−9 M |
PgR004_g249 | − 8.12 | rps28 40S ribosomal protein S28 | TBZ 10−7 M |
PgB15_g052 | − 6.84 | Uncharacterised | TBZ 10−9 M |
PgE153_g002 | − 6.84 | Tubulin beta-1 chain | TBZ 10−5 M |
PgR022X_g030 | − 6.83 | Uncharacterised | TBZ 10−9 M |
PgR011_g087 | − 6.76 | Uncharacterised | TBZ 10−9 M |
PgE193_g002 | − 6.70 | cyb-3 G2/mitotic-specific cyclin-B3 | TBZ 10−5 M |
PgR022X_g031 | − 6.46 | Uncharacterised | TBZ 10−9 M |
PgR005X_g207 | − 6.32 | cup-4 Acetylcholine receptor-like protein cup-4 | TBZ 10−7 M |