Table 2 Most frequent outcomes identified in the context of Lyme disease

Rheumatologic

7 [21,22,23, 25, 26, 28, 29]

Including Lyme arthritis, myalgia, or other musculoskeletal manifestations

Neurological

7 [21,22,23, 25, 26, 28, 29]

Including encephalopathy, peripheral neuropathy, neuroborrelisosis, bell palsy and meningitis

Cardiological

6 [22, 23, 25, 26, 28, 29]

Including Lyme carditis or other defined cardiac sequelae

Dermatological

5 [22, 25, 26, 28, 29]

Including erythema migrans, acrodermatitis and chronica atrophicans

System challenges

5 [6, 20, 27, 30, 36]

Frustration with diagnostic delay, access issues, multiple providers, out-of-network providers and other negative system experiences

Adverse events

4 [19, 20, 25, 35]

Including major and minor events related to antibiotic treatment or vaccination strategies

Quality of life

4 [16, 17, 27, 30]

Including quality-adjusted life-year measures or other specific health related quality of life estimates

Other Lyme sequelae

3 [25, 26, 29]

Including lymphocytoma, ocular manifestations, headache, acute back pain and neck pain

Psychological

2 [6, 30]

Including stress, anxiety, or depression