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Fig. 2 | Parasites & Vectors

Fig. 2

From: Fasciola gigantica excretory-secretory products (FgESPs) modulate the differentiation and immune functions of buffalo dendritic cells through a mechanism involving DNMT1 and TET1

Fig. 2

FgESPs induce apoptosis of buffalo DCs in vitro. a Buffalo DCs occurred morphological structure changes as representative of apoptotic features after the treatment of FgESPs for 48 h. b Caspase-3/7 activity was significantly increased in buffalo DCs after incubation with FgESPs. c The mRNA expression level of pro-apoptotic marker Bax was significantly upregulated, while the anti-apoptotic genes Bcl-2 and Mcl-1 were both downregulated in the FgESPs-treated DCs. The data are represented as the relative mRNA expression level, calculated by 2ΔΔCq method. Representative histograms from three independent experiments are shown. All data are presented as the mean ± standard error (SE) of triplicate measurements. **P < 0.01

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