Term
|
Estimate
|
SE
|
95% CI
|
---|
Lower
|
Upper
|
---|
Fixed effects
|
Intercept (CC, BP)a
|
0.776
|
0.352
|
0.087
|
1.465
|
Intervention period (IP)b
|
0.028
|
0.341
|
− 0.641
|
0.697
|
Intervention cluster (IC)
|
− 0.436
|
0.317
|
− 1.056
|
0.185
|
IP × ICc
|
− 1.086
|
0.227
|
− 1.532
|
− 0.641
|
Temperatured
|
0.721
|
0.139
|
0.448
|
0.994
|
Random effects SD
|
Dwelling ID
|
0.956
|
–
|
0.773
|
1.183
|
Month
|
0.456
|
–
|
0.303
|
0.686
|
- aThe intercept estimates the (log-scale) expected mean number of mosquitoes caught per 10 min aspiration in the CC, in the typical dwelling and at typical temperatures, during the BP; the other fixed-effect slope coefficients estimate changes in this expectation associated with period, cluster, intervention, and temperature effects
- bNote that the model estimates a near-zero change in (log) mean mosquito-catch as the CC entered the IP (but received no intervention); the estimated incidence rate ratio is e0.028 = 1.028, or a 2.8% increase in mean mosquito-catch, with the 95% CI spanning zero
- cThe ‘IP × IC’ interaction coefficient estimates the (log) change in expected mean mosquito-catch that can be attributed to the intervention – deployment of 150 pyriproxyfen dissemination stations over 13 months (the intervention period ‘IP’) in the intervention cluster ‘IC’. Here, the model estimates an e− 1.086 = 0.337 incidence rate ratio, indicating that the intervention resulted in a 100 − 33.7 = 66.3% reduction (95% CI: 47.3–78.4%) of the expected mean mosquito-catch
- dSpecified as the (standardized) mean of minimum daily temperatures in the month before each sampling occasion (‘tmin_m’); the original variable had mean = 17.39°C and SD = 1.73°C. Given our focus on estimating adjusted intervention effects, we considered weather covariates as confounders; ‘tmin_m’ yielded better-performing models, as measured by BIC scores, than other measures of temperature and rainfall
- Abbreviations: BIC, Bayesian information criterion; SE, standard error; 95% CI, 95% confidence interval (lower/upper limits); CC, control cluster; BP, baseline period; IP, intervention period; IC, intervention cluster; SD, standard deviation; ID, identity of each sampling dwelling