Fig. 2

Localization of the mutations found in the San Alfonso resistant strain in the voltage-gated para-sodium channel. a Sequence alignment of the sequence that codes for domain II of the reference sequence (ref; GenBank: AF134216.2) and the one obtained from the San Alfonso strain (SA), the G184C nucleotide substitution is highlighted in yellow and the C190A substitution is highlighted in green. b Sequence alignment of the sequence that codes for domain III of the reference sequence (ref) and the one obtained from the San Alfonso strain (SA), the T2134A nucleotide substitution is highlighted in red and the G2157T substitution is highlighted in blue. c Transmembrane topology of the para-sodium channel: the characteristic four trans-membrane domains (I–IV) are shown as clusters of 6 blue cylinders; domain linkers are shown as black loops. Mutations are represented by colored circles