Fig. 4

Body weight (a), hematocrit (b) and platelet counts (c) (mean ± standard deviation) of the uninfected control (CTL) and BALB/c mice inoculated with 1 × 10⁷Babesia microti and treated with either vehicle, artesunate (ARS) 25 mg/kg, mefloquine (MEF) 10 mg/kg or 50 mg/kg, artesunate (ARS) 25 mg/kg + mefloquine (MEF) 10 mg/kg or 50 mg/kg (5 mice per group). a Infected mice receiving mefloquine 50 mg/kg in both groups showed discomfort after drug administration and were subjected to euthanasia by day 8. Infected mice in the other groups showed transient loss of weight at day 10, around the peak parasitemia, and then recovered, and there were no significant differences in body weight changes between the groups. Infected mice of all groups showed marked decreases in hematocrit (b) and platelet counts (c), but there were no significant differences between the groups