Insights into the phylogenetic relationships and drug targets of Babesia isolates infective to small ruminants from the mitochondrial genomes

Wang, Xiaoxing; Wang, Jinming; Liu, Junlong; Liu, Aihong; He, Xin; Xiang, Quanjia; Li, Youquan; Yin, Hong; Luo, Jianxun; Guan, Guiquan

doi:10.1186/s13071-020-04250-8

Table 4 Main resistance-related mutations and drug binding residues of cytochrome b in Saccharomyces cerevisiae, Plasmodium falciparum, B. microti, B. duncani and six ovine Babesia isolates

From: Insights into the phylogenetic relationships and drug targets of Babesia isolates infective to small ruminants from the mitochondrial genomes

Target protein	Drug	Amino acid changes conferring drug resistance in the yeast numbering system	S. cerevisiae residues	P. falciparum residues	B. microti residues	B. duncani residues	BspXJ/DH residues	BmLT/TZ residues	BmNX/HB residues
Qo site of the bc1 complex	Atovaquone	Ile²⁶⁹→Met, Phe²⁷⁸→Ile, Phe²⁷⁸→Ala, Tyr²⁷⁹→Cys, Tyr²⁷⁹→Ser, Leu²⁸²→Val, Leu²⁷⁵→Phe	Glu²⁷², Leu²⁷⁵, Phe²⁷⁸, Tyr²⁷⁹	Glu²⁶¹, Phe²⁶⁷, Tyr²⁶⁸	Glu²⁶⁵, Leu²⁶⁸, Phe²⁷¹, Tyr²⁷²	Glu²⁵⁷, Leu²⁶⁰, Phe²⁶³, Tyr²⁶⁴	Glu²⁵⁹, Leu²⁶², Phe²⁶⁵, Tyr²⁶⁶	Glu²⁵⁹, Leu²⁶², Phe²⁶⁵, Tyr²⁶⁶	Glu²⁵⁹, Leu²⁶², Phe²⁶⁵, Tyr²⁶⁶
	Stigmatellin	Leu²⁷⁵→Phe	Glu²⁷²	Glu²⁶¹	Glu²⁶⁵	Glu²⁵⁷	Glu²⁵⁹	Glu²⁵⁹	Glu²⁵⁹
	Myxothiazol	Leu²⁷⁵→Phe	Leu²⁷⁵	–	Leu²⁶⁸	Leu²⁶⁰	Leu²⁶²	Leu²⁶²	Leu²⁶²
	ELQ-110	Met¹³⁹, Gly¹⁴³, Glu²⁷²	Met¹³⁹, Gly¹⁴³, Glu²⁷²	Met¹³³, Gly¹³⁷, Glu²⁶¹	Met¹³⁴, Gly¹³⁸, Glu²⁶⁵	Met¹²⁶, Gly¹³⁰, Glu²⁵⁷	Met¹²⁸, Gly¹³², Glu²⁵⁹	Met¹²⁸, Gly¹³², Glu²⁵⁹	Met¹²⁸, Gly¹³², Glu²⁵⁹
Qi site of the bc1 complex	Antimycin A	Asn³¹, Ser³⁴, Gly³⁷, Met²²¹, Phe²²⁵, Lys²²⁸, Asp²²⁹	Ser³⁴, His²⁰², Lys²²⁸, Asp²²⁹	His¹⁹², Asp²¹⁸	His¹⁹³, Asp²²⁰	His¹⁸⁵, Asp²¹²	His¹⁸⁷, Asp²¹⁴	His¹⁸⁷, Asp²¹⁴	His¹⁸⁷, Asp²¹⁴
Qi site of the bc1 complex	ELQ-300	Ile²⁶→Leu, Asp²²⁹	Ile²⁶, Asp²²⁹	Ile²², Asp²¹⁸	Asp²²⁰	Ile15, Asp²¹²	Asp²¹⁴	Asp²¹⁴	Asp²¹⁴
Qi and Qo sites of the bc1 complex	NQNO	Trp³⁰, Asn³¹, Gly³³, Gly³⁷, His²⁰⁴, Ser²⁰⁶, Met²²¹, Phe²²⁵	His²⁰², Ser²⁰⁶, Asp²²⁹	His¹⁹², Ser¹⁹⁶, Asp²¹⁸	His¹⁹³, Ser¹⁹⁷, Asp²²⁰	His¹⁸⁵, Ser¹⁸⁹, Asp²¹²	His¹⁸⁷, Ser¹⁹¹, Asp²¹⁴	His¹⁸⁷, Ser¹⁹¹, Asp²¹⁴	His¹⁸⁷, Ser¹⁹¹, Asp²¹⁴

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ISSN: 1756-3305

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