Table 2 Mean live Ixodes holocyclus counts and efficacy relative to control at 72 h after treatment and after weekly re-infestations for dogs treated with a single oral dose of Simparica Trio™ or NexGard Spectra^® on Day 0

Control

 Range

17–27

17–27

23–28

21–27

17–29

19–28

 Arithmetic mean (AM)

21.88

20.88

25.00

24.25

23.13

23.13

 Geometric mean (GM)^a

21.64

20.69

24.95

24.18

22.86

22.94

Simparica Trio™

 Range

0–0

0–0

0–2

0–0

0–1

0–0

 Arithmetic mean (AM)

0.00

0.00

0.38

0.00

0.13

0.00

 AM Efficacy (%)

100

100

98.50

100

99.46

100

 Geometric mean (GM)^a

0.00

0.00

0.25

0.00

0.09

0.00

 GM Efficacy (%)

100

100

98.99

100

99.60

100

 Test statistic vs control

t₍₃₄₎= 28.97

t₍₃₄₎= 28.53

t₍₄₈₎= 27.10

t₍₄₁₎= 23.66

t₍₃₃₎= 17.13

t₍₃₆₎= 29.05

 P-value vs control

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

NexGard Spectra^®

 Range

0–0

0–0

0–0

0–1

0–2

0–1

 Arithmetic mean (AM)

0.00

0.00

0.00

0.25

0.50

0.25

 AM Efficacy (%)

100

100

100

98.97

97.84

98.92

 Geometric mean (GM)^a

0.00

0.00

0.00

0.19

0.36

0.19

 GM Efficacy (%)

100

100

100

99.22

98.41

99.18

 Test statistic vs control

t₍₃₄₎= 28.97

t₍₃₄₎= 28.53

t₍₄₈₎= 29.10

t₍₄₁₎= 22.39

t₍₃₃₎= 15.89

t₍₃₆₎= 27.47

 P-value vs control

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

< 0.0001

 Test statistic vs Simparica Trio™

t₍₃₄₎= 0.00

t₍₃₄₎= 0.00

t₍₄₈₎= -2.00

t₍₄₁₎= 1.27

t₍₃₃₎= 1.24

t₍₃₆₎= 1.59

 P-value vs Simparica Trio™

1.0000

1.0000

0.0511

0.2109

0.2225

0.1217