Fig. 2

Conserved catalytic serine residue in acetylcholinesterase (AChE) targeted by insecticides in diverse organisms. The sequences shown are from Drosophila melanogaster (DROME), Tetronarce californica (TETCF), Mus musculus (MOUSE), Homo sapiens (HUMAN), Bos taurus (BOVIN), Rattus norvegicus (RAT), Caenorhabditis elegans (CAEEL), An. stephensi (ANOST), An. gambiae (ANOGA), Culex pipiens (CULPI), An. sinensis (ANOSI), Aedes aegypti (AEDAE). The name of each organism starts with its UniProt accession number. Conserved catalytic serine is shown by a black arrow. The catalytic serine residue is conserved across insects (1–2 and 4–7), mammals (10–13), birds (9), nematode (3) and fish (8). * indicates positions that have single and conserved amino acid residues; : indicates conservation between amino acid residues of strongly similar properties; . indicates conservation between amino acid residues of weakly similar properties