Protein cysteine S-nitrosylation provides reducing power by enhancing lactate dehydrogenase activity in Trichomonas vaginalis under iron deficiency

Cheng, Wei-Hung; Huang, Kuo-Yang; Ong, Seow-Chin; Ku, Fu-Man; Huang, Po-Jung; Lee, Chi-Ching; Yeh, Yuan-Ming; Lin, Rose; Chiu, Cheng-Hsun; Tang, Petrus

doi:10.1186/s13071-020-04355-0

Table 1 Proteomics identification of cysteine S-nitrosylated proteins in T. vaginalis

From: Protein cysteine S-nitrosylation provides reducing power by enhancing lactate dehydrogenase activity in Trichomonas vaginalis under iron deficiency

Functional classification	Gene product	Gene ID	IR	ID
Protein synthesis/ribosomal proteins	Ribosomal protein L14	TVAG_026460	+
	Ribosomal protein S13p/S18e	TVAG_020480	+
	Putative translation initiation inhibitor	TVAG_035410	+
	Ribosomal protein L24	TVAG_038050	+
	Ribosomal protein S3	TVAG_106800	+
	Ribosomal protein	TVAG_128790	+
	40S ribosomal protein S4	TVAG_131210	+
	RNA-binding protein	TVAG_158990	+
	40S ribosomal protein S5	TVAG_163180	+
	Ribosomal protein L13e	TVAG_423320	+
	Ribosomal protein L8	TVAG_005910	+	+
	Ribosomal protein L29	TVAG_013870	+	+
	Ribosomal protein L36e	TVAG_020530	+	+
	40S ribosomal protein S6	TVAG_033590	+	+
	60S ribosomal protein L7-2	TVAG_054130	+	+
	Elongation factor 1-alpha	TVAG_067400	+	+
	60S ribosomal protein L30	TVAG_072050	+	+
	40S ribosomal protein S8	TVAG_066030	+	+
	Ribosomal protein L10a	TVAG_074480	+	+
	Ribosomal protein L22	TVAG_083260	+	+
	Ribosomal protein L5	TVAG_113720	+	+
	40S ribosomal protein S7	TVAG_143030	+	+
	Ribosomal protein L23	TVAG_160160	+	+
	Ribosomal protein L35Ae	TVAG_185880	+	+
	Ribosomal protein L7Ae	TVAG_199270	+	+
	Ribosomal protein S24e	TVAG_272960	+	+
	60S ribosomal protein L18a	TVAG_347250	+	+
	Ribosomal protein L34e	TVAG_417810	+	+
	Ribosomal protein S14	TVAG_464120	+	+
	Ribosomal protein L24e	TVAG_101690		+
	Ribosomal protein L13e	TVAG_112230		+
	Ribosomal protein L38e	TVAG_246730		+
	Ribosomal protein S19e	TVAG_352520		+
Carbohydrate metabolism	Pyruvate:ferredoxin oxidoreductase A-like protein (Fragment)	TVAG_198110	+
	Malate dehydrogenase	TVAG_204360	+
	Malate dehydrogenase	TVAG_253650	+
	Phosphoglycerate kinase	TVAG_268050	+
	Fructose-1,6-bisphosphate aldolase	TVAG_300000	+
	Glyceraldehyde-3-phosphate dehydrogenase	TVAG_146910	+	+
	Hydrogenosomal malic enzyme subunit B proprotein	TVAG_238830	+	+
	Succinate-CoA ligase [ADP-forming] subunit alpha	TVAG_318670	+	+
	Enolase 2	TVAG_329460	+	+
	l-lactate dehydrogenase	TVAG_171090		+
	Phosphoenol pyruvate carboxykinase	TVAG_310250		+
	Fructose-1,6-bisphosphate aldolase	TVAG_345360		+
Cytoskeleton	Putative actin depolymerizing factor	TVAG_192620	+
Cytoskeleton	Actin (Fragment)	TVAG_512800	+	+
Antioxidant	Thioredoxin reductase	TVAG_474980		+
Proteolysis	Ubiquitin	TVAG_069570	+
Other	Adenosylhomocysteinase	TVAG_210320	+
	QXW lectin repeat family protein	TVAG_261950	+
	Cytosolic repetitive antigen	TVAG_427040	+
	Plectin/S10 domain containing protein	TVAG_329340	+	+
	TolA	TVAG_411090	+	+
	HMG box family protein	TVAG_325010		+
Unknown	Uncharacterized protein	TVAG_196630	+
	Uncharacterized protein	TVAG_198100	+
	Uncharacterized protein	TVAG_210380	+
	Uncharacterized protein	TVAG_219770	+
	Uncharacterized protein	TVAG_539120	+
	Uncharacterized protein	TVAG_010560	+	+
	Uncharacterized protein	TVAG_071700	+	+
	Uncharacterized protein	TVAG_083700	+	+
	Uncharacterized protein	TVAG_111510	+	+
	Uncharacterized protein	TVAG_121550	+	+
	Uncharacterized protein	TVAG_210010	+	+
	Uncharacterized protein	TVAG_226630	+	+
	Uncharacterized protein	TVAG_296920	+	+
	Uncharacterized protein	TVAG_306370	+	+
	Uncharacterized protein	TVAG_487100	+	+

Notes: SNO modified proteins identified in iron-rich (IR) and -deficient (ID) conditions by proteomics analysis were listed in this table. “+” represented the proteins `detected in IR and/ or ID conditions

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ISSN: 1756-3305

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