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Table 2 Number of Dirofilaria immitis-infected dogs treated with Moxi-Doxy according to pulmonary evaluation and antigen detection

From: Efficacy of semi-annual therapy of an extended-release injectable moxidectin suspension and oral doxycycline in Dirofilaria immitis naturally infected dogs

Pulmonary evaluation

No. of dogs (%)

Day 0

First negative antigen test

Second negative antigen test

Cough

7 (36.8)a

1 (5.3)b

1 (5.3)b

Dyspnea

3 (15.8)a

1 (5.3)b

0 (0)b

Harsh expiratory sounds

16 (84.2)a

11 (57.9)b

2 (10.5)c

Worm present at echocardiography

7 (36.8)a

3 (15.8)b

0 (0)c

Caudal pulmonary artery enlargement

8 (42.1)a

5 (26.3)b

2 (10.5)c

Main pulmonary artery enlargement

8 (42.1)a

4 (21.1)b

3 (15.8)b

Bronchial + interstitial pattern

19 (100)

19 (100)

18 (94.7)

Micronodular pattern

6 (31.6)a

9 (47.4)b

7 (36.8)a

  1. Notes: Moxi-Doxy, semi-annual treatments with extended-release injectable moxidectin and oral doxycycline. Different letters in rows indicate significant differences (P < 0.05)