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Table 2. Clinical description of infected subjects before (BT) and 6 months after treatment (6M AT)

From: Systemic profile of immune factors in an elderly Italian population affected by chronic strongyloidiasis

 

Baseline—BT (n = 32)

6M AT (n = 32)

P-value

Eosinophils (cells/µl), median (IQR)

815 (550–1078)

245 (117.5–367.5)

< 0.0001

Eosinophils (%), median (IQR)

10.45 (6.4–14.55)

3.16 (1.465–5.6)

< 0.0001

WBC (cells/µl), median (IQR)

7470 (6600–9305)

7425 (6168–8308)

ns

S. stercoralis stool exam, n (%)

< 0.0001

 Positive

15 (47%)

0

 

 Negative

16 (50%)

29 (91%)

 

 Unknown

1 (3%)

3 (9%)

 

S. stercoralis IFAT titre, n (%)a

< 0.0001

 ≤ 160

11 (34%)

28 (88%)

 

 > 160

20 (63%)

3 (9%)

 

S. stercoralis qPCR, n (%)

< 0.0001

 Positive

14 (44%)

1 (3%)

 

 Negative

16 (50%)

28 (88%)

 

 Unknown

2 (6%)

3 (9%)

 

Clinical symptoms BT, n (%)

 Present

22 (69%)

na

 

 Absent

10 (31%)

na

 

Detailed clinical symptomsb, n (%)

 Pruritus

17 (77%)

na

 

 Skin rash

9 (41%)

na

 

 Abdominal pain/distension

3 (14%)

na

 

 Respiratory symptoms

6 (27%)

na

 

Clinical symptoms 6M ATb, n (%)

 Improved

na

13 (59%)

 

 Persist

na

7 (32%)

 

 Ceased

na

2 (9%)

 

Response to treatment 12M ATc, n (%)

 Yes

24 (75%)

na

 

 No

8 (25%)

na

 

Response to treatment 6M ATd, n (%)

 Yes

22 (69%)

na

 

 No

10 (31%)

na

 
  1. aMissing information for one subject, who had positive serology by ELISA
  2. bComputed over the 22 subjects with clinical manifestations at baseline
  3. cResponse determined 12 months after treatment completion as primary outcome
  4. dResponse determined 6 months after treatment as secondary outcome
  5. Notes: Statistical significance was assessed using the Wilcoxon signed rank test for continuous variables or with the Fisher’s exact test for categorical variables. Statistical significance was set at P < 0.05
  6. Abbreviations: IQR, interquartile range; WBC, white blood cells; na, not applicable; ns, not significant