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Table 4 Demographic details and the distribution of the severity of clinical signs of trachoma in the study and evaluation sample population

From: DjinniChip: evaluation of a novel molecular rapid diagnostic device for the detection of Chlamydia trachomatis in trachoma-endemic areas

 

All (Time-point 14)

Retained in test evaluation

Reference test

DjinniChip test

Ct-negative

Ct-positive

Ct-negative

Ct-positive

N

428

350

297

53

298

52

Median age (range)

10 (7–15)

10 (7–15)

10 (7–14)

9 (7–14)

10 (7–14)

9 (7–14)

Sex: female, n (%)

194 (45.3)

161 (46)

152 (52.9)

32 (60)

157 (52.7)

32 (61.5)

F-score, n (%)

 0

353 (82.5)

283 (80.9)

266 (89.6)

17 (32.1)

257 (86.2)

26 (50.0)

 1

36 (8.4)

29 (8.3)

21 (7.1)

8 (15.1)

22 (7.4)

7 (13.5)

 2

21 (4.9)

20 (5.7)

9 (3.0)

11 (20.7)

12 (4.0)

8 (15.4)

 3

18 (4.2)

18 (5.1)

1 (0.3)

17 (32.1)

7 (2.4)

11 (21.2)

P-score, n (%)

 0

391 (91.3)

317 (90.6)

284 (95.6)

33 (62.2)

277 (93.0)

40 (76.9)

 1

23 (5.4)

20 (5.7)

8 (2.7)

12 (22.6)

14 (4.7)

6 (11.5)

 2

8 (1.9)

7 (2.0)

3 (1.0)

4 (7.6)

3 (1.0)

4 (7.7)

 3

6 (1.4)

6 (1.7)

2 (0.7)

4 (7.6)

4 (1.3)

2 (3.9)

C-score, n (%)

 0

397 (92.8)

328 (93.7)

275 (92.9)

52 (98.1)

278 (93.6)

49 (94.2)

 1

26 (6.0)

19 (5.4)

19 (6.4)

0

17 (5.7)

2 (3.9)

 2

5 (1.2)

3 (0.9)

2 (0.7)

1 (1.9)

2 (0.7)

1 (1.9)

 3

0

0

0

0

0

0

  1. FPC-scores: Clinical signs were graded using the 1981 WHO Detailed Trachoma Grading System (FPC). This divides the clinical signs into several four-point (0–3) increasing severity scales: follicles (F), papillary inflammation (P), and conjunctival scarring (C). This system corresponds to the WHO Simplified Trachoma Grading System in the following way: trachomatous inflammation-follicular (TF) is equivalent to F2/F3 and trachomatous inflammation-intense (TI) is equivalent to P3. DjinniChip and qPCR testing was performed at KCRI-BL, Moshi, Tanzania