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Fig. 1 | Parasites & Vectors

Fig. 1

From: Identification and characterization of a Babesia bigemina thrombospondin-related superfamily member, TRAP-1: a novel antigen containing neutralizing epitopes involved in merozoite invasion

Fig. 1

Sequence analysis of Babesia bigemina TRAP-1 (BbiTRAP-1) gene. a Schematic representation of the BbiTRAP-1 gene in the BOND strain with its five exons and the encoded polypeptide containing a signal peptide (SP), von Willebrand factor A (vWFA), a thrombospondin type-1 repeat domain (TSP-1), tandem repeats and the transmembrane region (TM) as well as a cytoplasmic tail domain (CTD). Asterisk indicates the presence of a tryptophan residue close to the CTD. b Schematic representation (not to scale) of the domains and repeats of three apicomplexan thrombospondin-related anonymous protein (TRAP) family proteins. Only long repeats (> 7 amino acids [aa]) are displayed as purple triangles. The triangles reflect the number of tandem repeat units with the exception of Babesia bovis TRAP-1 which has 11 repeat units in the T2Bo strain. The GenBank accession numbers of the corresponding genes are PF13_0201 (Plasmodium falciparum) and EDO06220.1 (B. bovis). The protein sizes in amino acids are shown on the right side. c Schematic representation (not to scale) of the domains and repeats of B. bigemina TRAP and thrombospondin-related protein (TRP) family proteins. Only long repeats (> 7aa) are displayed as purple triangles

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