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Table 1 Half maximal and maximal inhibitory concentrations of endochin-like quinolone (ELQ)-300 and ELQ-316 calculated for the four studied species of apicomplexan parasites at 72 h of culture

From: Endochin-like quinolone-300 and ELQ-316 inhibit Babesia bovis, B. bigemina, B. caballi and Theileria equi

Species

ELQ-300

ELQ-16

IC50 (nM)

IC100 (nM)

IC50 (nM)

IC100 (nM)

Babesia bovis

0.09 ± 0.002

4.2 ± 0.10

0.07

3.8 ± 0.12

B. bigemina

0.37 ± 0.19

1.3 ± 0.05

0.05

3.0 ± 0.15

B. caballi

0.19 ± 0.04

5.7 ± 0.24

0.1 ± 0.006

6.0 ± 0.18

Theilera equi

0.04 ± 0.003

3.36 ± 0.83

0.002

1.0 ± 1.55

  1. Values in table are presented as the mean and standard deviation (SD) based on triplicates for each experiment.
  2. IC50 and IC100, half maximal and maximal inhibitory concentrations, respectively
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Parasites & Vectors

ISSN: 1756-3305

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