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Table 1 Follow-up of Lutzomyia longipalpis mortality and insecticidal efficacy after blood meal on dogs for up to 12 months (360 days) after treatment with a single oral dose of fluralaner (Bravecto®)

From: Fluralaner (Bravecto®) induces long-term mortality of Lutzomyia longipalpis after a blood meal in treated dogs

Days after treatment Control Fluralaner Efficacy (%)c P valued
Mortality (%)a 95% Confidence intervalb Mortality (%)a 95% Confidence intervalb
1 12 (15) 0.77–0.92 80 (100) NAe 100 0.0002*
30 12 (15) 0.77–0.92 80 (100) NA 100 0.0002*
60 10 (12.5) 0.80–0.94 80 (100) NA 100 < 0.0001*
90 11 (13.75) 0.78–0.93 80 (100) NA 100 < 0.0001*
120 12 (15) 0.77–0.92 80 (100) NA 100 0.0002*
150 11 (13.75) 0.78–0.93 80 (100) NA 100 < 0.0001*
180 11 (13.75) 0.77–0.92 58 (72.5) 0.17–0.37 68.1 0.0015*
210 11 (13.75) 0.78–0.93 50 (62.5) 0.26–0.48 56.5 0.0049*
240 10 (12.5) 0.80–0.94 49 (61.25) 0.28–0.49 55.7 0.0022*
270 12 (15) 0.77–0.92 40 (50) 0.39–0.60 41.2 0.0171*
300 12 (15) 0.77–0.92 34 (42.5) 0.46–0.68 32.3 0.0590
330 12 (15) 0.77–0.92 19 (23.75) 0.66–0.85 10.3 0.0301
360 11 (13.75) 0.78–0.93 12 (15) 0.77–0.92 1.4 1.0000
  1. aMortality indicates the number of sand flies dead at the specified time point. Presented as the number of dead sand flies with the percentage [(dead females after blood-feeding/total number of blood-fed females)  × 100] in parentheses
  2. b95% Confidence interval is the interval of the probability of survival at the specified time point calculated using the Kaplan–Meier method
  3. cEfficacy is the percentage of sand fly mortality after exposure to the insecticide using Abbott’s formula
  4. dP value: Significance of difference in sand fly mortality between control group and fluralaner group using Fisher’s exact test. *Significant difference between treated dogs and control dogs at P ≤  0.05
  5. eNA: Samples showed 100% death rate