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Fig. 2 | Parasites & Vectors

Fig. 2

From: IPSE, a urogenital parasite-derived immunomodulatory molecule, suppresses bladder pathogenesis and anti-microbial peptide gene expression in bacterial urinary tract infection

Fig. 2

Effects of H-IPSE on UTI-associated bladder pathogenesis. H-IPSE reduces bladder pathogenesis. “PBS-UTI”: mice given PBS vehicle tail vein injections prior to UTI challenge; “H-IPSE+UTI”: mice administered the H06 ortholog of IPSE before UTI challenge; “H-IPSENLS-+UTI”: mice given a nuclear localization sequence mutant of the H06 ortholog of IPSE prior to UTI challenge; “NEG”: unmanipulated mice. ANOVAs with Tukey’s multiple comparisons test were used for comparisons between group means with every other group. Bars represent means and standard deviation. Findings were considered statistically significant at p < 0.05. *, **, ***, and **** denote p < 0.05, p < 0.01, p < 0.001, and p < 0.0001, respectively. Data are representative of two independent experiments

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Parasites & Vectors

ISSN: 1756-3305

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