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Table 1 Biochemical reference intervals for healthy bare-nosed wombats (Vombatus ursinus and southern hairy-nosed wombats(Lasiorhinus latifrons) obtained from the literature together with the mean, minimum and maximum values obtained from healthy bare-nosed wombats at all time points during the 25 mg/kg and 85 mg/kg trials

From: Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use

Biochemical parameter

Reference intervals

25 mg/kg trial (n = 5)

85 mg/kg trial (n = 2)

BNW

SHNW

Mean

(Min–max)

Mean

(Min–max)

Sodium (mmol/l)

128.8–154.8

132.0–143.0

136.0a

129.0–146.0

136.9

135.0–140.0

Potassium (mmol/l)

1.4–17.1

4.1–10.8

5.4

4.0–8.4

5.4a

4.6–7.1

Chloride (mmol/l)

81.0–106.2

87.7–101.9

93.4

82.0–102.0

93.4

88.0–97.0

Bi-carbonate (mmol/l)

24.9–43.4

31.0–54.6

34.5a

27.0–47.0

32.2a

29.0–37.0

Sodium:potassium ratio

18.6–32.1

9.4–29.4

25.4a

16.4–35.3

25.7

19.0–29.8

Anion gap (mmol/l)

9.5–20.9

–

13.6a

2.0–23.2

16.7

12.5–19.6

Urea (mmol/l)

0.6–19.3

3.4–16.8

10.4

5.7–17.9

7.5

5.4–10.5

Creatinine (μmol/l)

34.0 – 278.8

72.4–307.6

80.0

40.0–130.0

91.0a

50.0–140.0

Phosphorous (mmol/l)

0.5–3.0

0.5–3.3

1.8

0.9–4.5

2.5a

1.8–5.1

Calcium (mmol/l)

1.9–3.4

2.3–2.7

2.6

2.3–3.5

2.5

2.3–2.7

Total protein (g/l)

46.1–86.5

54.5–72.5

62.2

57.0–70.0

58.8

54.0–64.0

Albumin (g/l)

20.2–38.2

22.0–43.0

34a

24.0–39.0

35.1

31.0–40.0

Globulin (g/lL)

16.9–53.6

17.0–37.8

28.2a

20.0–37.0

23.7

22.0–27.0

Albumin: globulin ratio

0.0–8.7

0.8–2.0

1.2a

0.7–1.9

1.5

1.2–1.7

Alkaline phosphatase (U/l)

0.0–1364.0

0.0–497.4

507.3a

242.0–884.0

920.7a

518.0–1339.0

Aspartate animotransferase (U/l)

0.0–186.8

4.0–73.8

60

42.0–111.0

59.8

41.0–100.0

Alanine aminotransferase (U/l)

0.0–162.6

0.4–93.0

35.2a

22.0–63.0

26.0

19.0–35.0

Creatine kinase (U/l)

0.0–5032.4

–

200.5

14.0–1593.0

463.3

26.0–2791.0

Cholesterol (mmol/l)

0.75–4.2

1.8–4.2

1.3

0.8–2.1

2.2a

1.4–2.9

  1. Parameters that deviated from reference intervals for bare-nosed or southern-hairy nosed wombats are highlighted in italics
  2. BNW, Bare-nosed wombat; min–max, minimum–maximum values; SHNW, southern hairy-nosed wombat
  3. aSignificant change observed over time-post fluralaner administration