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Table 1 Biochemical reference intervals for healthy bare-nosed wombats (Vombatus ursinus and southern hairy-nosed wombats(Lasiorhinus latifrons) obtained from the literature together with the mean, minimum and maximum values obtained from healthy bare-nosed wombats at all time points during the 25 mg/kg and 85 mg/kg trials

From: Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use

Biochemical parameter Reference intervals 25 mg/kg trial (n = 5) 85 mg/kg trial (n = 2)
BNW SHNW Mean (Min–max) Mean (Min–max)
Sodium (mmol/l) 128.8–154.8 132.0–143.0 136.0a 129.0–146.0 136.9 135.0–140.0
Potassium (mmol/l) 1.4–17.1 4.1–10.8 5.4 4.0–8.4 5.4a 4.6–7.1
Chloride (mmol/l) 81.0–106.2 87.7–101.9 93.4 82.0–102.0 93.4 88.0–97.0
Bi-carbonate (mmol/l) 24.9–43.4 31.0–54.6 34.5a 27.0–47.0 32.2a 29.0–37.0
Sodium:potassium ratio 18.6–32.1 9.4–29.4 25.4a 16.4–35.3 25.7 19.0–29.8
Anion gap (mmol/l) 9.5–20.9 – 13.6a 2.0–23.2 16.7 12.5–19.6
Urea (mmol/l) 0.6–19.3 3.4–16.8 10.4 5.7–17.9 7.5 5.4–10.5
Creatinine (μmol/l) 34.0 – 278.8 72.4–307.6 80.0 40.0–130.0 91.0a 50.0–140.0
Phosphorous (mmol/l) 0.5–3.0 0.5–3.3 1.8 0.9–4.5 2.5a 1.8–5.1
Calcium (mmol/l) 1.9–3.4 2.3–2.7 2.6 2.3–3.5 2.5 2.3–2.7
Total protein (g/l) 46.1–86.5 54.5–72.5 62.2 57.0–70.0 58.8 54.0–64.0
Albumin (g/l) 20.2–38.2 22.0–43.0 34a 24.0–39.0 35.1 31.0–40.0
Globulin (g/lL) 16.9–53.6 17.0–37.8 28.2a 20.0–37.0 23.7 22.0–27.0
Albumin: globulin ratio 0.0–8.7 0.8–2.0 1.2a 0.7–1.9 1.5 1.2–1.7
Alkaline phosphatase (U/l) 0.0–1364.0 0.0–497.4 507.3a 242.0–884.0 920.7a 518.0–1339.0
Aspartate animotransferase (U/l) 0.0–186.8 4.0–73.8 60 42.0–111.0 59.8 41.0–100.0
Alanine aminotransferase (U/l) 0.0–162.6 0.4–93.0 35.2a 22.0–63.0 26.0 19.0–35.0
Creatine kinase (U/l) 0.0–5032.4 – 200.5 14.0–1593.0 463.3 26.0–2791.0
Cholesterol (mmol/l) 0.75–4.2 1.8–4.2 1.3 0.8–2.1 2.2a 1.4–2.9
  1. Parameters that deviated from reference intervals for bare-nosed or southern-hairy nosed wombats are highlighted in italics
  2. BNW, Bare-nosed wombat; min–max, minimum–maximum values; SHNW, southern hairy-nosed wombat
  3. aSignificant change observed over time-post fluralaner administration
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