Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use

Wilkinson, Vicky; Takano, Kotaro; Nichols, David; Martin, Alynn; Holme, Roz; Phalen, David; Mounsey, Kate; Charleston, Michael; Kreiss, Alexandre; Pye, Ruth; Browne, Elizabeth; Næsborg-Nielsen, Christina; Richards, Shane A.; Carver, Scott

doi:10.1186/s13071-020-04500-9

Table 5 Behavioural monitoring data for bare-nosed wombats in the 25 mg/kg trial (B1, B2, B3, Z1 and Z2) and 85 mg/kg (B4 and B1a) fluralaner safety trials

From: Fluralaner as a novel treatment for sarcoptic mange in the bare-nosed wombat (Vombatus ursinus): safety, pharmacokinetics, efficacy and practicable use

ID	Age	Sex	Time	Day	Sleeping	Basking	Exploring	Feeding	Handling
B1	Adult	Female	1430–1630	− 1	12	0	0	0	0
B1			1040–1640	0	17	0	5	2	0
B1			1430–1630	1	10	2	0	0	0
B1			1430–1630	2	12	0	0	0	0
B1			1430–1630	3	12	0	0	0	0
B1			1430–1630	4	10	2	0	0	0
B1			1430–1630	7	12	0	0	0	0
B1			1430–1630	8	12	0	0	0	0
B1			1430–1630	9	12	0	0	0	0
B1			1430–1630	10	12	0	0	0	0
B1			1430–1630	11	12	0	0	0	0
B1			1430–1630	14	12	0	0	0	0
B1			1430–1630	17	12	0	0	0	0
B1			1430–1630	21	12	0	0	0	0
B1			1430–1630	24	12	0	0	0	0
B1			1430–1630	28	10	2	0	0	0
B1			1430–1630	31	12	0	0	0	0
B1			1430–1630	35	12	0	0	0	0
B1			1430–1630	38	12	0	0	0	0
B1			1430–1630	41	12	0	0	0	0
B1			1430–1630	48	12	0	0	0	0
B1			1430–1630	53	12	0	0	0	0
B1			1430–1630	60	12	0	0	0	0
B1			1430–1630	67	12	0	0	0	0
B1			1430–1630	81	12	0	0	0	0
B1			1430–1630	89	12	0	0	0	0
B2	Juvenile	Female	1430–1630	− 1	9	0	2	0	1
B2			1040–1640	0	10	0	6	7	1
B2			1430–1630	1	3	0	4	5	0
B2			1430–1630	2	1	0	4	6	1
B2			1430–1630	3	10	0	1	1	0
B2			1430–1630	4	8	0	0	4	0
B2			1430–1630	7	6	1	0	5	0
B2			1430–1630	8	0	0	4	5	3
B2			1430–1630	9	6	0	5	0	1
B2			1430–1630	10	4	0	0	7	1
B2			1430–1630	11	0	0	8	2	2
B2			1430–1630	14	6	3	0	3	0
B2			1430–1630	17	1	0	5	4	2
B2			1430–1630	21	6	0	3	1	2
B2			1430–1630	24	4	0	2	6	0
B2			1430–1630	28	10	0	0	2	0
B2			1430–1630	31	7	0	0	4	1
B2			1430–1630	35	4	0	3	3	2
B2			1430–1630	38	2	0	3	5	2
B2			1430–1630	41	4	0	0	7	1
B2			1430–1630	48	0	1	4	6	1
B2			1430–1630	53	3	1	5	1	2
B2			1430–1630	60	12	2	3	5	2
B2			1430–1630	67	0	0	8	3	1
B2			1430–1630	81	0	0	4	6	2
B2			1430–1630	89	3	3	1	3	2
B3	Juvenile	Female	1430–1630	− 1	10	0	0	0	2
B3			1430–1630	0	10	0	0	0	2
B3			1430–1630	1	9	0	0	1	2
B3			1430–1630	2	6	0	1	3	2
B3			1430–1630	3	10	0	0	1	1
B3			1430–1630	4	4	0	0	4	4
B3			1430–1630	7	10	0	0	0	2
B3			1430–1630	8	10	0	0	0	2
B3			1430–1630	9	3	0	2	2	5
B3			1430–1630	10	12	0	0	0	0
B3			1430–1630	11	12	0	0	0	0
B3			1430–1630	14	12	0	0	0	0
B3			1430–1630	17	6	0	1	0	5
B3			1430–1630	21	10	0	0	0	2
B3			1430–1630	24	7	0	0	2	3
B3			1430–1630	28	12	0	0	0	0
B3			1430–1630	31	10	0	0	0	2
B3			1430–1630	35	10	0	0	0	2
B3			1430–1630	38	7	0	1	2	2
B3			1430–1630	41	10	0	0	0	2
B3			1430–1630	48	12	0	0	0	0
B3			1430–1630	53	8	0	0	0	4
B3			1430–1630	60	12	0	0	0	0
B3			1430–1630	67	12	0	0	0	0
B3			1430–1630	81	6	1	2	1	2
B3			1430–1630	95	12	0	0	0	0
Z1	Adult	Female	1430–1630	− 1	7	2	3	0	0
Z1			1040–1640	0	4	0	2	6	0
Z1			1430–1630	1	10	0	0	2	0
Z1			1430–1630	2	7	0	0	5	0
Z1			1430–1630	3	10	0	0	2	0
Z1			1430–1630	4	8	0	0	4	0
Z1			1430–1630	7	10	0	0	2	0
Z1			1430–1630	8	12	0	0	0	0
Z1			1430–1630	9	10	0	0	2	0
Z1			1430–1630	10	11	0	0	1	0
Z1			1430–1630	11	12	0	0	0	0
Z1			1430–1630	14	9	0	2	1	0
Z1			1430–1630	17	12	0	0	0	0
Z1			1430–1630	21	11	0	0	1	0
Z1			1430–1630	24	12	0	0	0	0
Z1			1430–1630	28	12	0	0	0	0
Z1			1430–1630	31	11	0	0	1	0
Z1			1430–1630	35	12	0	0	0	0
Z1			1430–1630	38	11	0	0	1	0
Z1			1430–1630	52	10	0	1	1	0
Z1			1430–1630	66	12	0	0	0	0
Z1			1430–1630	80	12	0	0	0	0
Z2	Adult	Male	1430–1630	− 1	12	0	0	0	0
Z2			1040–1640	0	7	0	2	3	0
Z2			1430–1630	1	8	0	3	1	0
Z2			1430–1630	2	7	0	3	2	0
Z2			1430–1630	3	4	0	6	2	0
Z2			1430–1630	4	9	0	0	3	0
Z2			1430–1630	7	10	0	0	2	0
Z2			1430–1630	8	10	0	0	2	0
Z2			1430–1630	9	10	0	0	2	0
Z2			1430–1630	10	12	0	0	0	0
Z2			1430–1630	11	12	0	0	0	0
Z2			1430–1630	14	12	0	0	0	0
Z2			1430–1630	17	10	0	0	2	0
Z2			1430–1630	21	10	0	1	1	0
Z2			1430–1630	24	12	0	0	0	0
Z2			1430–1630	28	12	0	0	0	0
Z2			1430–1630	31	12	0	0	0	0
Z2			1430–1630	35	10	0	2	0	0
Z2			1430–1630	38	7	0	4	1	0
Z2			1430–1630	52	7	0	4	1	0
Z2			1430–1630	66	8	1	3	0	0
Z2			1430–1630	80	10	0	2	0	0
B4	Juvenile	Female	1300–1500	0	10	0	0	0	2
B4			1300–1500	2	11	0	0	0	1
B4			1300–1500	4	10	0	0	1	1
B4			1300–1500	7	11	0	0	0	1
B4			1300–1500	14	6	0	0	2	2
B4			1300–1500	21	8	2	0	1	1
B4			1300–1500	35	9	0	0	0	3
B4			1300–1500	49	11	0	0	0	1
B4			1300–1500	63	9	0	3	0	0
B4			1300–1500	77	10	0	0	0	2
B1a	Juvenile	Female	1300–1500	0	8	0	1	2	1
B1a			1300–1500	2	8	1	0	1	2
B1a			1300–1500	4	9	2	0	0	1
B1a			1300–1500	7	10	0	0	0	2
B1a			1300–1500	14	12	0	0	0	0
B1a			1300–1500	21	11	0	1	0	0
B1a			1300–1500	35	12	0	0	0	0
B1a			1300–1500	49	12	0	0	0	0
B1a			1300–1500	63	12	0	0	0	0
B1a			1300–1500	77	12	0	0	0	0

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ISSN: 1756-3305

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