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Fig. 1 | Parasites & Vectors

Fig. 1

From: Fowlerstefin, a cysteine protease inhibitor of Naegleria fowleri, induces inflammatory responses in BV-2 microglial cells in vitro

Fig. 1

Multiple sequence alignment and phylogenetic analysis. a Multiple sequence alignment. The deduced amino acid sequence of fowlerstefin was aligned with sequences of related proteins from other parasites and humans. Gaps are introduced into the sequences to maximize the alignment. The QVVAG cystatin motif is indicated as a red bold line above the sequence. The predicted N-terminal signal peptide sequences are underlined. No putative N-glycosylation site was identified in the fowlerstefin sequence. Potential disulfide bridges are shown with brackets, while cysteine residues are boxed. b Phylogenetic analysis. The tree was built by the neighbor-joining method using MEGA 4. Numbers at the branches indicate bootstrap proportions (1000 replicates)

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