Fig. 2
A metabolic map related to LPG synthesis in Leishmania. a The LPG molecule, composed of four main parts (GPI anchor, core, repeat unit and cap). The branched polysaccharide residues that usually compose this molecule are shown, and the sites where LPG-related gene products act for the synthesis of this molecule are displayed together with the gene name in yellow boxes. SCGR/L family genes proposed to participate in side chain formation are highlighted in salmon boxes. Genes that are involved in the synthesis of the repeat unit and core regions are shown, while those that form the GPI anchor appear in b. c The conversion of d-arap into GDP-d-Arap by the dual kinase/pyrophosphorylase activity of AFKP80, and the transport of GDP-d-Arap and UDP-Gal into the Golgi apparatus. Abbreviations: Ara, arabinose; d-Arap, d-arabinopyranose; EtN, ethanolamine; Gal, galactose; Galf, galactosylfuranose; GlcN, glucosamine; GlcNAc, N-acetyl glucosamine; Ino, inositol; Man, mannose