Table 1 Frequency (%) of nonsynonymous mutations in Pvmdr1 in the China–Myanmar border area and central China
Amino acida | China–Myanmar border | Central China (n = 55) | ||
|---|---|---|---|---|
2008 (n = 27) | 2012–2013 (n = 129) | 2015 (n = 119) | ||
P8L | 0 | 0 | 0 | 17.9 |
T409M | 0 | 9.3 | 13.7 | 0 |
S513R | 55.5 | 46.5 | 11.1 | 0 |
G520D | 0 | 13.9 | 8.5 | 48.8 |
G698S | 88.9 | 97.7 | 100 | 100 |
L845F | 14.8 | 3.1 | 2.6 | 52.7 |
A861E | 14.8 | 24.8 | 26.5 | 29.1 |
M908L | 100 | 99.2 | 98.3 | 100 |
V945G | 0 | 0 | 13.7 | 0 |
T958M | 100 | 100 | 100 | 100 |
Y976F | 18.5 | 1.5 | 0 | 0 |
F1076L | 33.3 | 41.7 | 77.8 | 100 |
K1393N | 29.6 | 45.7 | 16.2 | 0 |
S1450L | 0 | 21.8 | 13.8 | 0 |