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Table 2 Diversity and neutrality tests of the Pvmdr1 gene in P. vivax populations from different areas of the GMS

From: Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

PopulationsSNPNo. of haplotypesHaplotype diversity (Hd ± SD)Nucleotide diversityNeutrality testsRm
SNSθwπDD*F*
China–Myanmar 2008 (n = 27)220210.983 ± 0.0140.00120.0010− 0.7839− 1.2499− 1.29504
China–Myanmar 2012–2013 (n = 129)815330.869 ± 0.0230.00090.00090.03160.03570.04046
China–Myanmar 2015 (n = 119)3459750.971 ± 0.0080.00390.0012− 2.2310**− 4.2879**− 4.0776**15
Central China (n = 55)717230.914 ± 0.0260.00100.0006− 1.1179− 2.1131− 2.09533
Thailand–Myanmar (n = 69)a1021440.974 ± 0.0090.00150.0009− 1.3670− 2.7450*− 2.6640*5
Thailand–Cambodia (n = 29)a77150.926 ± 0.0260.00080.0007− 0.4540− 0.9490− 0.93204
  1. aAnalysis has been done in these populations on a near full-length Pvmdr1 gene (4264 bp)
  2. Abbreviations: S, synonymous; NS, nonsynonymous; SD, standard deviation; D, Tajima’s D; D*, Fu & Li’s D*, F*: Fu & Li’s F*, Rm, minimum recombination events
  3. *P < 0.05, **P < 0.02