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Table 4 Codon-based tests for selection on Pvmdr1 gene in parasite populations at various sites of the GMS

From: Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

PopulationsFELSLACFUBAR
China–Myanmar 2008 (n = 27)Positively selected: 513, 1076Positively selected: nonePositively selected: 513, 845, 1076, 1393
Negatively selected: 44, 399, 529, 756, 1358, 1396Negatively selected: 44, 529, 1358Negatively selected: 44, 181, 399, 529, 687, 756, 1358, 1396
China–Myanmar 2012–2013 (n = 129)Positively selected: 513Positively selected: nonePositively selected: 513, 698, 845, 861, 976, 1076, 1393, 1450
Negatively selected: 44, 493, 529, 1348, 1396Negatively selected: 44, 529Negatively selected: 44, 493, 529, 1348, 1396
China–Myanmar 2015 (n = 119)Positively selected: 861, 908, 926Positively selected: nonePositively selected: 231, 359, 409, 513, 562, 599, 612, 618, 838, 861, 896, 908, 926, 936, 951, 959, 1219, 1393, 1450
Negatively selected: 23, 44, 214, 220, 298, 322, 347, 493, 501, 529, 554, 555, 574, 585, 587, 865, 910, 917, 939, 1004, 1190, 1233, 1238, 1358Negatively selected: 44, 529, 322, 555, 574, 910, 1358Negatively selected: 23, 44, 214, 220, 298, 322, 347, 493, 501, 529, 554, 555, 574, 585, 587, 865, 910, 917, 925, 939, 1004, 1067, 1190, 1233, 1238, 1348, 1358
Central China 2004–2008 (n = 55)Positively selected: nonePositively selected: nonePositively selected: 8, 520, 845, 1233, 1390
Negatively selected: 44, 687Negatively selected: 1464Negatively selected: 44, 75, 248, 529, 687, 1390
Thailand–Myanmar border (n = 69)Positively selected: 698Positively selected: 698Positively selected: 513, 698, 861, 976, 1076, 1393
Negatively selected: 44, 529, 1396Negatively selected: 44, 172, 493, 529, 913, 1396Negatively selected: 44, 172, 493, 529, 913, 1396
Thailand–Cambodia border (n = 29)Positively selected: nonePositively selected: nonePositively selected: 1076
Negatively selected: 44, 312, 529Negatively selected: 44, 312Negatively selected: 44, 312, 529, 908