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Table 4 Codon-based tests for selection on Pvmdr1 gene in parasite populations at various sites of the GMS

From: Evolution of the Plasmodium vivax multidrug resistance 1 gene in the Greater Mekong Subregion during malaria elimination

Populations

FEL

SLAC

FUBAR

China–Myanmar 2008 (n = 27)

Positively selected: 513, 1076

Positively selected: none

Positively selected: 513, 845, 1076, 1393

Negatively selected: 44, 399, 529, 756, 1358, 1396

Negatively selected: 44, 529, 1358

Negatively selected: 44, 181, 399, 529, 687, 756, 1358, 1396

China–Myanmar 2012–2013 (n = 129)

Positively selected: 513

Positively selected: none

Positively selected: 513, 698, 845, 861, 976, 1076, 1393, 1450

Negatively selected: 44, 493, 529, 1348, 1396

Negatively selected: 44, 529

Negatively selected: 44, 493, 529, 1348, 1396

China–Myanmar 2015 (n = 119)

Positively selected: 861, 908, 926

Positively selected: none

Positively selected: 231, 359, 409, 513, 562, 599, 612, 618, 838, 861, 896, 908, 926, 936, 951, 959, 1219, 1393, 1450

Negatively selected: 23, 44, 214, 220, 298, 322, 347, 493, 501, 529, 554, 555, 574, 585, 587, 865, 910, 917, 939, 1004, 1190, 1233, 1238, 1358

Negatively selected: 44, 529, 322, 555, 574, 910, 1358

Negatively selected: 23, 44, 214, 220, 298, 322, 347, 493, 501, 529, 554, 555, 574, 585, 587, 865, 910, 917, 925, 939, 1004, 1067, 1190, 1233, 1238, 1348, 1358

Central China 2004–2008 (n = 55)

Positively selected: none

Positively selected: none

Positively selected: 8, 520, 845, 1233, 1390

Negatively selected: 44, 687

Negatively selected: 1464

Negatively selected: 44, 75, 248, 529, 687, 1390

Thailand–Myanmar border (n = 69)

Positively selected: 698

Positively selected: 698

Positively selected: 513, 698, 861, 976, 1076, 1393

Negatively selected: 44, 529, 1396

Negatively selected: 44, 172, 493, 529, 913, 1396

Negatively selected: 44, 172, 493, 529, 913, 1396

Thailand–Cambodia border (n = 29)

Positively selected: none

Positively selected: none

Positively selected: 1076

Negatively selected: 44, 312, 529

Negatively selected: 44, 312

Negatively selected: 44, 312, 529, 908