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Table 2 Efficacy of imidacloprid 10%/moxidectin 1% spot-on in prevention and treatment of Aelurostrongylus abstrusus infection as determined in three controlled studies

From: Efficacy of imidacloprid 10%/moxidectin 1% spot-on formulation (Advocate®) in the prevention and treatment of feline aelurostrongylosis

Study

Group

Cats with ≥ 1 worm

Totala/viableb worm burdenc

Efficacy (%)

Adequacy of infection

1

(1) Control

8

28.8 (11–68)a

na

Yes**

(2) Advocate® (SD 36)

7

3.4* (0–18)a

88.3

na

2

(1) Control

8

14.3 (4–42)b

na

Yes**

(2) Advocate® SD 10 + SD 18

0

0*b

100

na

(3) Advocate® SD 53, 81, 109

1

0.1* (0–1)b

99.4

na

3

(1) Control

8

32.6 (3–86)b

na

Yes**

(2) Advocate® SD 4 + SD 24

0

0*b

100

na

(3) Advocate® SD 10 + SD 18

0

0*b

100

na

(4) Advocate® SD 20 + SD 8

0

0*b

100

na

  1. aEfficacy calculation based on total worm counts
  2. bEfficacy calculation based on viable worm counts
  3. cGeometric mean (range)
  4. *Significantly different (P < 0.05) compared to control group
  5. **Lower bound of 95% confidence interval greater than 10% of the geometric mean
  6. Abbreviation: na, not applicable