Skip to main content

Advertisement

Table 2 Arithmetic mean flea counts and percent efficacy relative to placebo at 24 h after treatment and weekly re-infestations with Ctenocephalides felis for dogs treated orally with Simparica Trio™, sarolaner-only, moxidectin-only or pyrantel-only tablets (Study 2)

From: Laboratory studies evaluating the efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) for the treatment and control of flea infestations on dogs

Day after treatmentTreatment groupFlea count% Efficacy
1Placebo70.1
Simparica Trio™0*100
Sarolaner0*100
Moxidectin65.56.6
Pyrantel66.65.0
7Placebo78.3
Simparica Trio™0*100
Sarolaner1.9*97.6
Moxidectin66.415.2
Pyrantel73.85.8
14Placebo65.8
Simparica Trio™0*100
Sarolaner0*100
Moxidectin70.60
Pyrantel76.80
21Placebo54.1
Simparica Trio™0.1*99.8
Sarolaner0.4*99.3
Moxidectin64.80.0
Pyrantel71.8a0.0
28Placebo86.6
Simparica Trio™0.3*99.7
Sarolaner0*100
Moxidectin78.98.9
Pyrantel63.5b26.7
35Placebo79.6
Simparica Trio™0*100
Sarolaner0.4*99.5
Moxidectin79.40.3
Pyrantel87.80
  1. *Flea counts are significantly lower than placebo; 7.78 ≤ t(35) ≤ 10.42, P < 0.0001
  2. aFlea count significantly higher than placebo; t(35) = − 3.00, P = 0.005
  3. bFlea count significantly lower than placebo; t(35) = 2.78, P = 0.0087