Laboratory studies evaluating the efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) for the treatment and control of flea infestations on dogs

Table 4 Arithmetic mean flea and egg counts and percent efficacy relative to placebo after treatment and weekly re-infestations with Ctenocephalides felis for dogs treated orally with Simparica Trio™ (Study 5)

Day after treatment	Treatment group	Flea count	% Efficacy	Egg count	% Efficacy
1	Placebo	73.8		364.0
1	Simparica Trio™	0*	100	0	100
7	Placebo	71.7		444.5
7	Simparica Trio™	0*	100	0	100
14	Placebo	67.0		496.2
14	Simparica Trio™	0*	100	0	100
21	Placebo	61.5		488.5
21	Simparica Trio™	0*	100	0	100
28	Placebo	60.8		440.6
28	Simparica Trio™	0*	100	0	100
35	Placebo	63.6		366.8
35	Simparica Trio™	0*	100	0	100

*Flea counts are significantly lower than placebo; 10.09 ≤ t₍₉₎ ≤ 41.72, P < 0.0001

ISSN: 1756-3305