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Table 3 Arithmetic mean tick counts and percent efficacy relative to placebo for dogs following one oral treatment with Simparica Trio™ with existing Dermacentor variabilis infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

StudyTick strainDayaPlacebobSimparica Trio™b% EfficacyTest statistic
MeanRangeMeanRange
5Oklahoma State Universityc234.020–440.10–199.7t(9.02) = 11.57, P < 0.0001
739.829–500.40–399.0t(9) = 20.32, P < 0.0001
14e39.130–460.10–199.7t(8.06) = 23.79, P < 0.0001
21e30.416–421.10–696.4t(8.06) = 11.16, P < 0.0001
28e31.223–422.30–1992.6t(8.59) = 15.04, P < 0.0001
35e31.624–414.20–2786.7t(8.68) = 10.59, P < 0.0001
6Ecto Services Incd226.816–420.30–298.9t(9.17) = 11.91, P < 0.0001
719.714–310.20–199.0t(9.09) = 10.55, P < 0.0001
1428.710–480.50–298.3t(9) = 8.16, P < 0.0001
2130.420–3800–0100t(9) = 17.67, P < 0.0001
2831.122–4100–0100t(9) = 14.56, P < 0.0001
3528.012–510.40–298.6t(9) = 7.79, P < 0.0001
  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 hours post-treatment and weekly re-infestation
  2. bTreatment with placebo or Simparica Trio™ (minimum dose 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Stillwater, OK, USA, in 1972 and was last supplemented with wild-caught ticks the same year as the study started
  4. dColony started from ticks field-collected in Stillwater, OK, USA, in 2015 (one year prior to study start)
  5. eStudy 5: Time-points with missing observations (Days 14–35) used least squares means and corresponding % efficacies