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Table 4 Arithmetic mean tick counts and percent efficacy relative to placebo following one oral treatment with Simparica Trio for dogs with existing Ixodes scapularis infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

StudyTick strainDayaPlacebobSimparica Trio™b% EfficacyTest statistic
MeanRangeMeanRange
7Oklahoma State Universityc221.914–3400–0100t(17) = 12.10, P < 0.0001
713.83–2000–0100t(17) = 9.34, P < 0.0001
1419.65–3100–0100t(18) = 8.72, P < 0.0001
2120.613–341.00–1095.1t(9) = 8.63, P < 0.0001
2821.69–3700–0100t(17) = 6.64, P < 0.0001
3523.210–3500–0100t(18) = 9.85, P < 0.0001
8Wild-caught ticksd226.720–3600–0100t(9) = 16.02, P < 0.0001
727.222–3500–0100t(9) = 19.47, P < 0.0001
1425.519–3200–0100t(9) = 20.27, P < 0.0001
2126.622–340.10–199.6t(9) = 21.84, P < 0.0001
2824.819–3300–0100t(9) = 17.18, P < 0.0001
3526.819–3700–0100t(9) = 17.73, P < 0.0001
  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 hours post-treatment and weekly re-infestation
  2. bTreatment with placebo or Simparica Trio (minimum dose 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Stillwater, OK, USA, in 1991 and was last supplemented with wild-caught ticks 10 months prior to study start
  4. dWild-caught adult ticks collected in South Carolina, USA, during the two months prior to study start