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Table 4 Arithmetic mean tick counts and percent efficacy relative to placebo following one oral treatment with Simparica Trio for dogs with existing Ixodes scapularis infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

Study

Tick strain

Daya

Placebob

Simparica Trio™b

% Efficacy

Test statistic

Mean

Range

Mean

Range

7

Oklahoma State Universityc

2

21.9

14–34

0

0–0

100

t(17) = 12.10, P < 0.0001

7

13.8

3–20

0

0–0

100

t(17) = 9.34, P < 0.0001

14

19.6

5–31

0

0–0

100

t(18) = 8.72, P < 0.0001

21

20.6

13–34

1.0

0–10

95.1

t(9) = 8.63, P < 0.0001

28

21.6

9–37

0

0–0

100

t(17) = 6.64, P < 0.0001

35

23.2

10–35

0

0–0

100

t(18) = 9.85, P < 0.0001

8

Wild-caught ticksd

2

26.7

20–36

0

0–0

100

t(9) = 16.02, P < 0.0001

7

27.2

22–35

0

0–0

100

t(9) = 19.47, P < 0.0001

14

25.5

19–32

0

0–0

100

t(9) = 20.27, P < 0.0001

21

26.6

22–34

0.1

0–1

99.6

t(9) = 21.84, P < 0.0001

28

24.8

19–33

0

0–0

100

t(9) = 17.18, P < 0.0001

35

26.8

19–37

0

0–0

100

t(9) = 17.73, P < 0.0001

  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 hours post-treatment and weekly re-infestation
  2. bTreatment with placebo or Simparica Trio (minimum dose 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Stillwater, OK, USA, in 1991 and was last supplemented with wild-caught ticks 10 months prior to study start
  4. dWild-caught adult ticks collected in South Carolina, USA, during the two months prior to study start