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Table 5 Arithmetic mean tick counts and percent efficacy relative to placebo for dogs following one oral treatment with Simparica Trio with existing Rhipicephalus sanguineus infestations and after subsequent weekly re-infestations

From: Efficacy of a novel orally administered combination product containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against induced infestations of five common tick species infesting dogs in the USA

StudyTick strainDayaPlacebobSimparica Trio™b% EfficacyTest statistic
MeanRangeMeanRange
9Bertek Incc223.812–400.10–199.6t(9.02) = 7.59, P < 0.0001
717.39–281.00–1094.2t(9) = 8.24, P < 0.0001
1411.73–171.20–1289.7t(18) = 5.98, P < 0.0001
2115.14–2600–0100t(18) = 7.00, P < 0.0001
2814.64–2600–0100t(17) = 6.46, P < 0.0001
3512.84–2600–0100t(17) = 5.50, P < 0.0001
10Ecto Services Incd234.729–460.10–199.7t(9) = 22.01, P < 0.0001
729.419–430.10–199.7t(9.03) = 12.80, P < 0.0001
1421.115–300.10–199.5t(9) = 13.95, P < 0.0001
2123.113–390.70–397.0t(9.46) = 8.89, P < 0.0001
2824.620–370.20–199.2t(9) = 16.78, P < 0.0001
3524.919–331.50–694.0t(12.3) = 13.68, P < 0.0001
  1. aFirst infestation on Day -2. Subsequent infestations on Day 5, 12, 19, 26 and 33. Tick counts were conducted at 48 hours post-treatment and weekly re-infestation
  2. bTreatment with placebo or Simparica Trio (minimum 1.2 mg/kg sarolaner, 24 µg/kg moxidectin and 5 mg/kg pyrantel (as pamoate salt)) occurred on Day 0
  3. cColony originated from ticks field-collected in Greenbrier, AR, USA, in 2006 and was last supplemented with wild-caught ticks ~ 2 years prior to study start
  4. dColony originated from ticks collected in 1991 from dogs in Stillwater, OK, USA, and was obtained from Professional Laboratory and Research Service, Inc (PLRS), Corapeake, NC, USA. Last supplementation of the colony with wild-caught ticks was 2–3 months prior to study start