Efficacy of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea and tick infestations on dogs presented as veterinary patients in Europe

Table 3 Efficacy of a single oral dose of Simparica Trio™ and afoxolaner+ milbemycin oxime against natural infestations with Ctenocephalides felis, Ctenocephalides canis, Pulex irritans and Archaeopsylla erinacei on dogs presented as veterinary patients in Europe

Treatment group	Study day	C. felis		C. canis		P. irritans		A. erinacei
Treatment group	Study day	Mean flea count	% Efficacy	Mean flea count	% Efficacy	Mean flea count	% Efficacy	Mean flea count	% Efficacy
Simparica Trio™	− 1 or 0	12.4		8.9		4.4		2.0
	14 ± 5	0.3	97.6	0	100	0	100	0	100
	30 ± 5	0.2	98.9	0	100	0	99.7	0	100
Afoxolaner + Milbemycin oxime	− 1 or 0	9.6		7.2		6.1		6.0
	14 ± 5	0.5	96.2	0	100	0.2	97.8	1.3	89.7
	30 ± 5	0.2	98.1	0	100	0	100	0	100.0

Note: Before treatment administration (on study day − 1 or 0) the number of dogs in the Simparica Trio™ and afoxolaner + milbemycin oxime groups infected with each species was 139 and 76 for C. felis, 33 and 17 for C. canis, 34 and 16 for P. irritans and 2 and 3 for A. erinacei, respectively

ISSN: 1756-3305