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Table 6 Efficacy of a single oral dose of Simparica Trio™ and afoxolaner+ milbemycin oxime against natural infestations with Ixodes ricinus, Rhipicephalus sanguineus, Dermacentor reticulatus and Ixodes hexagonus on dogs presented as veterinary patients in Europe

From: Efficacy of a novel oral chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea and tick infestations on dogs presented as veterinary patients in Europe

Treatment groupStudy dayI. ricinusR. sanguineusD. reticulatusI. hexagonus
Mean tick count% EfficacyMean tick count% EfficacyMean tick count% EfficacyMean tick count% Efficacy
Simparica Trio™− 1 or 03.513.71.81.0
7 ± 20.199.11.196.601000100
14 ± 20.198.80.893.901000100
21 ± 20.199.10.297.201000100
30 ± 40100.00.297.001000100
Afoxolaner + Milbemycin oxime− 1 or 03.315.32.02.7
7 ± 20.395.20.997.801000100
14 ± 20.196.90.697.901000100
21 ± 20.196.40.199.301000100
30 ± 4099.50.399.101000100
  1. Notes: Before treatment administration (on study day − 1 or 0) the number of dogs in the Simparica Trio™ and afoxolaner + milbemycin oxime groups infected with each species was 71 and 35 for I. ricinus, 60 and 30 for R. sanguineus, 28 and 16 for D. reticulatus and 3 and 3 for I. hexagonus, respectively