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Table 1 Adult Angiostrongylus vasorum worm counts in Study 1: percent efficacy and statistical comparisons to placebo

From: Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

TreatmentMoxidectin dose (µg/kg)aGeometric mean worm count% EfficacyTest statistic
Placebo053.8
Sarolaner + moxidectin + pyrantel349.97.2t(21) = 0.23,
P = 0.8169
Sarolaner + moxidectin + pyrantel1224.454.5t(21) = 2.45,
P = 0.0234
Sarolaner + moxidectin + pyrantel242.994.7t(21) = 8.47,
P < 0.0001b
  1. aThe combination product-treated dogs received the exact moxidectin dose shown for each group, combined with 2 mg/kg sarolaner and 5 mg/kg pyrantel
  2. bAdult worm counts significantly lower compared to the 3 µg/kg and the 12 µg/kg groups (6.02 ≤ t(21) ≤ 8.23, P < 0.0001)