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Table 1 Adult Angiostrongylus vasorum worm counts in Study 1: percent efficacy and statistical comparisons to placebo

From: Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

Treatment

Moxidectin dose (µg/kg)a

Geometric mean worm count

% Efficacy

Test statistic

Placebo

0

53.8

Sarolaner + moxidectin + pyrantel

3

49.9

7.2

t(21) = 0.23,

P = 0.8169

Sarolaner + moxidectin + pyrantel

12

24.4

54.5

t(21) = 2.45,

P = 0.0234

Sarolaner + moxidectin + pyrantel

24

2.9

94.7

t(21) = 8.47,

P < 0.0001b

  1. aThe combination product-treated dogs received the exact moxidectin dose shown for each group, combined with 2 mg/kg sarolaner and 5 mg/kg pyrantel
  2. bAdult worm counts significantly lower compared to the 3 µg/kg and the 12 µg/kg groups (6.02 ≤ t(21) ≤ 8.23, P < 0.0001)