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Table 4 Studies 2 and 3: Angiostrongylus vasorum L1 counts in the feces and lung, percent efficacy, mean percent consolidated lung lobe area and mean total lung lesion severity scores by treatment group

From: Efficacy of orally administered combination of moxidectin, sarolaner and pyrantel (Simparica Trio™) for the prevention of experimental Angiostrongylus vasorum infection in dogs

StudyGroupaFecal L1 countsbLung L1 countsLung lesionsc
Geometric mean% EfficacyGeometric mean% Efficacy% Lung consolidationMean total severity score
Study 2Placebo2.349157.454.511.3
Simparica Trio™01000.01001.92.7
Study 3Placebo3.793336.259.012.0
Simparica Trio™0.05098.71.999.41.20.9
  1. aThe Simparica Trio™-treated dogs received 24 µg/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel
  2. bFecal L1 counts (per gram feces) were conducted daily on samples collected before necropsy for 3 days
  3. cAt necropsy the percentage of consolidation for each of the six lung lobes was assessed and the mean % consolidation was calculated. The severity of the lesions on each lobe was scored on a scale from 0 to 3 (the maximum possible total score was 18)