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Table 1 Arithmetic mean live Dermacentor reticulatus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel pamoate and efficacy relative to placebo (Study 1)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Count dayPlaceboSarolaner (mg/kg) + moxidectin (µg/kg) + pyrantel (mg/kg)
Mean0.6 + 12 + 2.51.2 + 24 + 52.4 + 48 + 10
Mean% EfficacyMean% EfficacyMean% Efficacy
234.1a0.1b99.60.2b98.90b100
728.6a0.6b95.60.1b99.60.1b99.6
1425.8a0.7b96.60.2b98.10b100
2123.8a1.7b87.40.2c98.90.3c97.9
2823.8a1.8b85.80.2c98.90c100
3525.3a3.3b79.70.9c95.00.2d99.0
  1. Note: Dogs infested with ticks from colony originated from Ireland and subsequently enriched with ticks from the Netherlands, the last time 4 years before study conduct. Mean live tick counts with the same superscript within rows are not significantly different (P > 0.05)