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Table 1 Arithmetic mean live Dermacentor reticulatus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel pamoate and efficacy relative to placebo (Study 1)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Count day

Placebo

Sarolaner (mg/kg) + moxidectin (µg/kg) + pyrantel (mg/kg)

Mean

0.6 + 12 + 2.5

1.2 + 24 + 5

2.4 + 48 + 10

Mean

% Efficacy

Mean

% Efficacy

Mean

% Efficacy

2

34.1a

0.1b

99.6

0.2b

98.9

0b

100

7

28.6a

0.6b

95.6

0.1b

99.6

0.1b

99.6

14

25.8a

0.7b

96.6

0.2b

98.1

0b

100

21

23.8a

1.7b

87.4

0.2c

98.9

0.3c

97.9

28

23.8a

1.8b

85.8

0.2c

98.9

0c

100

35

25.3a

3.3b

79.7

0.9c

95.0

0.2d

99.0

  1. Note: Dogs infested with ticks from colony originated from Ireland and subsequently enriched with ticks from the Netherlands, the last time 4 years before study conduct. Mean live tick counts with the same superscript within rows are not significantly different (P > 0.05)