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Table 2 Arithmetic mean live Dermacentor reticulatus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel and efficacy relative to placebo (Study 2)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Count dayPlacebo1.2 mg/kg sarolaner + 24 µg moxidectin + 5 mg/kg pyrantelTest statistic (vs placebo)
MeanRangeMeanaRange% Efficacy
229.820–370.30–199.2t(14) = 23.43
P < 0.0001
736.530–4500100t(14) = 79.48
P < 0.0001
1430.315–370.10–199.6t(14) = 24.22
P < 0.0001
2133.620–470.10–199.6t(14) = 25.55
P < 0.0001
2835.822–451.00–597.2t(14) = 11.42
P < 0.0001
3524.718–363.90–1584.3t(14) = 12.22
P < 0.0001
  1. Note: Dogs infested with ticks from colony originated from the UK and subsequently enriched with ticks from Slovakia, Germany and the Netherlands, the last time 2 years before study conduct
  2. aMean live tick count significantly lower than placebo (11.42 ≤t(14) ≤ 79.48, P < 0.0001) at all time points