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Table 3 Arithmetic mean live Ixodes hexagonus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel and efficacy relative to placebo (Study 3)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Count dayPlacebo1.2 mg/kg sarolaner + 24 µg moxidectin + 5 mg/kg pyrantelTest statistic (vs placebo)
MeanRangeMeanaRange% Efficacy
216.510–2700100t(14.6) = 29.09
P < 0.0001
717.58–2400100t(14.7) = 21.55
P < 0.0001
1417.49–2500100t(14.9) = 24.93
P < 0.0001
2116.613–2100100t(13.3) = 50.30
P < 0.0001
2819.515–2300100t(13.9) = 63.54
P < 0.0001
3517.612–260.30–298.6t(13.9) = 17.16
P < 0.0001
  1. Note: Dogs infested with ticks from colony originated with ticks from Belgium the same year as study conduct
  2. aMean live tick count significantly lower than placebo (17.16 ≤ tdf ≤ 63.54, 13.3 ≤ df ≤ 14.9, P < 0.0001) at all time-points