Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Table 3 Arithmetic mean live Ixodes hexagonus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel and efficacy relative to placebo (Study 3)

Count day	Placebo		1.2 mg/kg sarolaner + 24 µg moxidectin + 5 mg/kg pyrantel			Test statistic (vs placebo)
Count day	Mean	Range	Mean^a	Range	% Efficacy	Test statistic (vs placebo)
2	16.5	10–27	0	0	100	t_(14.6) = 29.09 P < 0.0001
7	17.5	8–24	0	0	100	t_(14.7) = 21.55 P < 0.0001
14	17.4	9–25	0	0	100	t_(14.9) = 24.93 P < 0.0001
21	16.6	13–21	0	0	100	t_(13.3) = 50.30 P < 0.0001
28	19.5	15–23	0	0	100	t_(13.9) = 63.54 P < 0.0001
35	17.6	12–26	0.3	0–2	98.6	t_(13.9) = 17.16 P < 0.0001

Note: Dogs infested with ticks from colony originated with ticks from Belgium the same year as study conduct
^aMean live tick count significantly lower than placebo (17.16 ≤ t_df ≤ 63.54, 13.3 ≤ df ≤ 14.9, P < 0.0001) at all time-points

ISSN: 1756-3305