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Table 4 Arithmetic mean live Ixodes ricinus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel and efficacy relative to placebo (Studies 4 and 5)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Tick strain originaCount dayPlacebo1.2 mg/kg sarolaner + 24 µg moxidectin + 5 mg/kg pyrantelTest statistic (vs placebo)
MeanRangeMeanbRange% Efficacy
Slovakia, Germany and Ireland (Slovakia and Ireland)215.49–2000100t(15.3) = 31.2
P < 0.0001
714.312–1800100t(11.8) = 57.63
P < 0.0001
1414.010–1600100t(9.4) = 46.63
P < 0.0001
2116.113–2000100t(13.8) = 54.8
P < 0.0001
2814.913–2000100t(12.8) = 55.78
P < 0.0001
3515.410–2000100t(14) = 27.15
P < 0.0001
Germany (Germany)215.93–2500100t(14.3) = 13.25
P < 0.0001
714.09–1800100t(14.2) = 38.09
P < 0.0001
1416.410–2200100t(14.2) = 35.42
P < 0.0001
2115.610–2100100t(14.2) = 32.02
P < 0.0001
2817.611–2300100t(13.8) = 32.93
P < 0.0001
3518.015–200.50–497.2t(14.1) = 13.34
P < 0.0001
  1. aCountries from which ticks were originally isolated to establish colony (countries of origin for ticks subsequently used to enrich colony the last time 1 and 2 years before study conduct, respectively)
  2. bMean live tick count significantly lower than placebo (Study 4: 17.16 ≤ tdf ≤ 63.54, 9.4 ≤ df ≤ 15.3; Study 5: 13.25 ≤ tdf ≤ 38.09, 13.8 ≤ df ≤ 14.3, P < 0.0001) at all time-points