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Table 5 Arithmetic mean live Rhipicephalus sanguineus counts for dogs dosed once orally with sarolaner + moxidectin + pyrantel and efficacy relative to placebo (Study 6)

From: Efficacy of a novel chewable tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against four common tick species infesting dogs in Europe

Count dayPlacebo1.2 mg/kg sarolaner + 24 µg moxidectin + 5 mg/kg pyrantelTest statistic (vs placebo)
MeanRangeMeanaRange% Efficacy
224.515–3600100t(71.8) = 17.79
P < 0.0001
724.319–320.30–299.0t(71.8) = 17.07
P < 0.0001
1427.411–420.60–297.7t(71.8) = 15.85
P < 0.0001
2125.415–370.40–298.5t(71.8) = 16.67
P < 0.0001
2824.418–320.60–397.4t(71.8) = 16.09
P < 0.0001
3526.419–350.80–297.2t(71.8) = 15.55
P < 0.0001
  1. Note: Dogs infested with ticks from colony originated with ticks from France and subsequently enriched with ticks from France and Greece, the last time 1 year before study conduct
  2. aMean live tick count significantly lower than placebo (15.55 ≤ t71.8 ≤ 17.79, P < 0.0001) at all time-points