Study | Isolate origin | Stage at time of treatment | Day of inoculationa | Day of treatment | Day of worm recovery | Treatment groupb | n | No. of infected dogs | Worm count range | Geometric mean worm count | Efficacy compared to placebo | |
---|---|---|---|---|---|---|---|---|---|---|---|---|
% Efficacy | Test statistic | |||||||||||
1 | Europe | L4 larvae | − 7 | 0 | 7 | Placebo | 9 | 9 | 11–36 | 21.0 | – | – |
Simparica Trio™ | 9 | 0 | 0 | 0 | 100 | t(7) = 21.62 P < 0.0001 | ||||||
2 | USA | L4 larvae | 8 | Placebo | 8 | 8 | 4–17 | 9.2 | – | – | ||
Simparica Trio™ | 8 | 1 | 0–2 | 0.1 | 98.4 | t(7) = 12.76 P < 0.0001 | ||||||
3 | USA | Immature adults (L5) | − 11 | 0 | 7 | Placebo | 8 | 8 | 110–260 | 209.9 | – | – |
Simparica Trio™ | 8 | 3 | 0–3 | 0.5 | 99.8 | t(7) = 22.77 P < 0.0001 | ||||||
4 | Europe | Immature adults (L5) | Placebo | 8 | 8 | 23–41 | 29.6 | – | – | |||
Simparica Trio™ | 8 | 0 | 0 | 0 | 100 | t(7) = 47.93 P < 0.0001 |