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Table 3 Geometric (arithmetic) mean live flea counts, ranges and efficacies for dogs dosed orally with Simparica Trio™ or afoxolaner

From: Safety and efficacy of a novel oral chewable combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea infestations in client-owned dogs in the USA

Count dayaSimparica Trio™Afoxolaner
nMeanbRange% EfficacynMeanbRange% Efficacy
014942.5 (102.5)10–28507334.5 (86.1)10–1220
301420.4 (1.5)c0–7299.0 (98.5)700.6 (4.5)c0–14898.3 (94.8)
601360.1 (0.3)c0–899.7 (99.7)680.1 (0.3)c0–499.6 (99.7)
  1. aDay 0 = pre-treatment count; Day 30 = Days 26 to 35; Day 60 = Days 54 to 66
  2. bTable displays the Day 0 geometric means from the Day 0 to Day 30 models. The Day 0 geometric means from the Day 0 to Day 60 model were 42.6 for the Simparica Trio™-treated group and 34.9 for the afoxolaner-treated group
  3. cMean flea count significantly lower than Day 0 (23.78 ≤ t(12) ≤ 36.51, P < 0.0001)