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Table 3 Geometric (arithmetic) mean live flea counts, ranges and efficacies for dogs dosed orally with Simparica Trio™ or afoxolaner

From: Safety and efficacy of a novel oral chewable combination tablet containing sarolaner, moxidectin and pyrantel (Simparica Trio™) against natural flea infestations in client-owned dogs in the USA

Count daya

Simparica Trio™

Afoxolaner

n

Meanb

Range

% Efficacy

n

Meanb

Range

% Efficacy

0

149

42.5 (102.5)

10–2850

–

73

34.5 (86.1)

10–1220

–

30

142

0.4 (1.5)c

0–72

99.0 (98.5)

70

0.6 (4.5)c

0–148

98.3 (94.8)

60

136

0.1 (0.3)c

0–8

99.7 (99.7)

68

0.1 (0.3)c

0–4

99.6 (99.7)

  1. aDay 0 = pre-treatment count; Day 30 = Days 26 to 35; Day 60 = Days 54 to 66
  2. bTable displays the Day 0 geometric means from the Day 0 to Day 30 models. The Day 0 geometric means from the Day 0 to Day 60 model were 42.6 for the Simparica Trio™-treated group and 34.9 for the afoxolaner-treated group
  3. cMean flea count significantly lower than Day 0 (23.78 ≤ t(12) ≤ 36.51, P < 0.0001)
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Parasites & Vectors

ISSN: 1756-3305

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