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Fig. 4 | Parasites & Vectors

Fig. 4

From: Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

Fig. 4

Ultrathin sections of amastigotes. Untreated control amastigote (a) and amastigotes treated with CsA (10 μM) (b), DHCsA-d (5 μM) (c), or SSG (9 μM) (d) for 48 h. Several different ultrastructural alterations were observed, such as autophagosomes (b) in the cytoplasm; intense disorganization and swelling can be observed in nuclei of the parasites (d), degraded amastigotes in large parasitophorous vacuoles were observed (c). Abbreviations: a, amastigote; A, autophagosome; F, flagellum; K, kineplast; M, mitochondrion; N, nucleus; PV, parasitophorous vacuole

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