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Table 1 IC50 of CsA, DHCsA-d, or SSG used for treatment of leishmanial promastigotes and intracellular amastigotes

From: Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

Compound

Promastigotes IC50

Amastigotes IC50

24 h

48 h

24 h

48 h

Mean ± SD (µM)

Mean ± SD (µM)

Mean ± SD (µM)

Mean ± SD (µM)

CsA

23.44 ± 0.3

15.88 ± 0.4

nd

nd

DHCsA-d

21.24 ± 1.2

12.14 ± 1.1

5.23 ± 2.1

4.84 ± 0.4

SSG

32.33 ± 1.6

20.23 ± 1.4

9.51 ± 0.5

8.27 ± 0.1

  1. Note: Data are represented as the mean ± SD of three independent experiments
  2. Abbreviations: IC50, 50% inhibitory concentration; nd, not determined; SD, standard deviation
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Parasites & Vectors

ISSN: 1756-3305

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