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Table 1 IC50 of CsA, DHCsA-d, or SSG used for treatment of leishmanial promastigotes and intracellular amastigotes

From: Evaluation of in vitro antileishmanial efficacy of cyclosporin A and its non-immunosuppressive derivative, dihydrocyclosporin A

CompoundPromastigotes IC50Amastigotes IC50
24 h48 h24 h48 h
Mean ± SD (µM)Mean ± SD (µM)Mean ± SD (µM)Mean ± SD (µM)
CsA23.44 ± 0.315.88 ± 0.4ndnd
DHCsA-d21.24 ± 1.212.14 ± 1.15.23 ± 2.14.84 ± 0.4
SSG32.33 ± 1.620.23 ± 1.49.51 ± 0.58.27 ± 0.1
  1. Note: Data are represented as the mean ± SD of three independent experiments
  2. Abbreviations: IC50, 50% inhibitory concentration; nd, not determined; SD, standard deviation