Skip to main content

Table 1 Drug susceptibility of the wild-type (WT) parent and the derived isolates exposed for five cycles to MIL

From: Phenotypic adaptations of Leishmania donovani to recurrent miltefosine exposure and impact on sand fly infection

Strain

Intracellular amastigote IC50 ± SE (µM)

Post-fly amastigote IC50 ± SE (µM)

Promastigote IC50 ± SE (µM)

Post-fly promastigote IC50 ± SE (µM)

BPK275/0-cl18 WT

2.4 ± 0.3

0.4 ± 0.1

5.8 ± 1.0

2.8 ± 0.3

BPK275/0-cl18 MIL

3.1 ± 0.4

1.4 ± 0.1

9.8 ± 1.2

4.5 ± 0.4

BPK282/0-cl4 WT

2.4 ± 0.4

0.6 ± 0.1

2.6 ± 0.8

5.0 ± 0.6

BPK282/0-cl4 MIL

1.2 ± 0.1

1.0 ± 0.2

9.7 ± 2.5

7.2 ± 1.3

  1. Notes: Susceptibility of the different strains is expressed as the average 50% inhibitory concentration (IC50) ± standard error of the mean (SE) and is the result of at least four independent experiments run in duplicate
Back to article page

Parasites & Vectors

ISSN: 1756-3305

Contact us