Fig. 4

Diagram of possible pathways of pathomechanism of disseminated acanthamoebiasis with eye infection [14, 42, 47, 50, 51] Abbreviations: BDNF, brain-derived neurotrophic factor; CD, cluster of differentiation; CNS; central nervous system; DAMPs, damage-associated molecular patterns; IL, interleukin; INF-α, interferon alpha; MMP-9, matrix metalloproteinases 9; NT-4, neurotrophin 4; ROS, reactive oxygen species; TIMP-1; tissue inhibitor of metalloproteinases 1; TLR, Toll like receptors; TNF-α, tumor necrosis factor alpha